Swallowing abnormalities and dyskinesia in Parkinson's disease
Identifieur interne : 003716 ( Main/Exploration ); précédent : 003715; suivant : 003717Swallowing abnormalities and dyskinesia in Parkinson's disease
Auteurs : Francisca Sueli Monte [Brésil] ; Francisco Pereira Da Silva-Júnior [Brésil] ; Pedro Braga-Neto [Brésil] ; Miguel Ngelo Nobre E Souza [Brésil] ; Veralice Meireles Sales De Bruin [Brésil]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Body Mass Index, Deglutition Disorders (chemically induced), Deglutition Disorders (diagnosis), Deglutition Disorders (physiopathology), Dyskinesia, Dyskinesia, Drug-Induced (etiology), Dysphagia, Female, Fluoroscopy (instrumentation), Humans, Levodopa, Levodopa (adverse effects), Male, Middle Aged, Nervous system diseases, Oropharynx (physiopathology), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Severity of Illness Index, Swallowing, Videotape Recording, dyskinesia, dysphagia, levodopa, swallowing.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemically induced : Deglutition Disorders.
- diagnosis : Deglutition Disorders.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- instrumentation : Fluoroscopy.
- physiopathology : Deglutition Disorders, Oropharynx.
- Aged, Body Mass Index, Female, Humans, Male, Middle Aged, Severity of Illness Index, Videotape Recording.
Abstract
Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20342
Affiliations:
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Le document en format XML
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first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name><affiliation wicri:level="1"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pharmacy, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author><author><name sortKey="Da Silva Nior, Francisco Pereira" sort="Da Silva Nior, Francisco Pereira" uniqKey="Da Silva Nior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name><affiliation wicri:level="1"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Medicine, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author><author><name sortKey="Braga Eto, Pedro" sort="Braga Eto, Pedro" uniqKey="Braga Eto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name><affiliation wicri:level="1"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Medicine, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author><author><name sortKey="Nobre E Souza, Miguel Ngelo" sort="Nobre E Souza, Miguel Ngelo" uniqKey="Nobre E Souza M" first="Miguel Ngelo" last="Nobre E Souza">Miguel Ngelo Nobre E Souza</name><affiliation wicri:level="1"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Medicine, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author><author><name sortKey="Sales De Bruin, Veralice Meireles" sort="Sales De Bruin, Veralice Meireles" uniqKey="Sales De Bruin V" first="Veralice Meireles" last="Sales De Bruin">Veralice Meireles Sales De Bruin</name><affiliation wicri:level="1"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Medicine, Federal University of Ceará</wicri:regionArea><wicri:noRegion>Federal University of Ceará</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-04">2005-04</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="457">457</biblScope><biblScope unit="page" to="462">462</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">76FF6C13A93651EE1F84F9950D7215213E7BE99D</idno><idno type="DOI">10.1002/mds.20342</idno><idno type="ArticleID">MDS20342</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Body Mass Index</term><term>Deglutition Disorders (chemically induced)</term><term>Deglutition Disorders (diagnosis)</term><term>Deglutition Disorders (physiopathology)</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dysphagia</term><term>Female</term><term>Fluoroscopy (instrumentation)</term><term>Humans</term><term>Levodopa</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Oropharynx (physiopathology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Severity of Illness Index</term><term>Swallowing</term><term>Videotape Recording</term><term>dyskinesia</term><term>dysphagia</term><term>levodopa</term><term>swallowing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Deglutition Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Deglutition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Fluoroscopy</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Deglutition Disorders</term><term>Oropharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Videotape Recording</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Dysphagie</term><term>Déglutition</term><term>Lévodopa</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Brésil</li></country></list><tree><country name="Brésil"><noRegion><name sortKey="Monte, Francisca Sueli" sort="Monte, Francisca Sueli" uniqKey="Monte F" first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name></noRegion><name sortKey="Braga Eto, Pedro" sort="Braga Eto, Pedro" uniqKey="Braga Eto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name><name sortKey="Da Silva Nior, Francisco Pereira" sort="Da Silva Nior, Francisco Pereira" uniqKey="Da Silva Nior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name><name sortKey="Nobre E Souza, Miguel Ngelo" sort="Nobre E Souza, Miguel Ngelo" uniqKey="Nobre E Souza M" first="Miguel Ngelo" last="Nobre E Souza">Miguel Ngelo Nobre E Souza</name><name sortKey="Sales De Bruin, Veralice Meireles" sort="Sales De Bruin, Veralice Meireles" uniqKey="Sales De Bruin V" first="Veralice Meireles" last="Sales De Bruin">Veralice Meireles Sales De Bruin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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